Russian researchers develop hybrid compounds to combat oxidative stress

A research team at Perm University in Russia has developed advanced hybrid compounds that combine phenol and pyruvate, acting as highly effective antioxidants even at low concentrations and in various environments within the body.

The researchers explained that the human body constantly produces free radicals, which serve useful functions in limited amounts, such as fighting bacteria. However, excess free radicals can damage cells, accelerate aging, and increase the risk of cardiovascular disease, diabetes, and inflammation.

The team noted that environmental pollution, stress, and poor nutrition raise oxidative stress levels, making it necessary to use external antioxidants like vitamins C and E. However, traditional antioxidants have limitations: some work only in aqueous environments, others only in fatty environments, and their effectiveness drops at low concentrations.

To address these challenges, the researchers created hybrid compounds by combining phenol and pyruvate, resulting in two molecules—one water-soluble and the other fat-soluble. Laboratory tests showed that the new compounds demonstrated 14% greater antioxidant activity than commercial counterparts at low concentrations.

Future prospects for advanced medicines

Anastasia Klimova, lead researcher from the university's Department of Chemical Engineering, said the two compounds showed a strong ability to bind and neutralize free radicals. She added that the fat-soluble compounds can function in both aqueous and fatty environments, offering greater flexibility and versatility compared to traditional antioxidants.

This innovation is significant as it opens new avenues for future research to develop drugs that could help treat cardiovascular diseases and chronic inflammation.